微生物群
败血症
失调
医学
免疫学
免疫系统
肠道微生物群
肠道微生物群
免疫
肠道菌群
重症监护医学
生物信息学
生物
作者
Nathan J. Klingensmith,Craig M. Coopersmith
出处
期刊:Surgical Infections
[Mary Ann Liebert]
日期:2023-04-01
卷期号:24 (3): 250-257
被引量:1
摘要
The gut has been hypothesized to be the “motor” of multiple organ dysfunction in sepsis. Although there are multiple ways in which the gut can drive systemic inflammation, increasing evidence suggests that the intestinal microbiome plays a more substantial role than previously appreciated. An English language literature review was performed to summarize the current knowledge of sepsis-induced gut microbiome dysbiosis. Conversion of a normal microbiome to a pathobiome in the setting of sepsis is associated with worsened mortality. Changes in microbiome composition and diversity signal the intestinal epithelium and immune system resulting in increased intestinal permeability and a dysregulated immune response to sepsis. Clinical approaches to return to microbiome homeostasis may be theoretically possible through a variety of methods including probiotics, prebiotics, fecal microbial transplant, and selective decontamination of the digestive tract. However, more research is required to determine the efficacy (if any) of targeting the microbiome for therapeutic gain. The gut microbiome rapidly loses diversity with emergence of virulent bacteria in sepsis. Restoring normal commensal bacterial diversity through various therapies may be an avenue to improve sepsis mortality.
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