The Efficacy and Safety of Endoscopic Submucosal Dissection (ESD) Combined With Radiofrequency Ablation (RFA) Sequential Therapy for Extensive Esophageal Lesions

Sequential ESD-RFA therapy significantly reduces stricture rates (30% vs. 60%, p = 0.02) and improves 12-month quality of life (SF-36: 82.55 vs. 74.40, p = 0.001) compared to ESD monotherapy, while maintaining equivalent complete remission rates (100% vs. 96.7%, p = 0.16). This approach is particularly advantageous for lesions > 10 cm or involving > 3/4 circumference.