Decellularized ECM from Blastema Krt42⁺ Cells Promotes Skin Regeneration via Immunometabolic Modulation of Macrophages

cells, large-scale ECM is successfully produced in vitro, with regenerative capabilities comparable to dRB. Mechanistic studies reveal that this novel ECM material reduces inflammation and promotes oxidative metabolism in macrophages, resulting in a pro-regenerative phenotype and enhanced secretion of growth factors. This study presents a novel ECM-based material with substantial potential to advance wound healing and tissue regeneration.