防御素
功能(生物学)
免疫系统
促炎细胞因子
细胞生物学
炎症
化学
生物
免疫学
生物化学
肽
作者
Xinyue Chang,Meng-Wei Meng,Linjie Zhang,Lian‐Qin Chai
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2023-10-01
卷期号:30 (10): 830-840
标识
DOI:10.2174/0109298665252235230919071229
摘要
The antibacterial and antiviral functions of human defensin 5 lay the foundation for its role as a core host protective component. In addition, HD5 also has the function of inhibiting tumor proliferation and immune regulation. However, everything has two sides; cytotoxic and proinflammatory properties may exist, while HD5 performs physiological functions. Accordingly, the modification and engineering of HD5 are particularly important. Therefore, this review summarizes the role of HD5 in various aspects of host defense, as well as modification of HD5 to ameliorate the biological activity, with a view to promoting the clinical use of HD5.
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