The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense

A recent study by Yang et al. 1 Yang C. Zhao Y. Wang L. Guo Z. Ma L. Yang R. Wu Y. Li X. Niu J. Chu Q. et al. De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence. Nat. Cell Biol. 2023; 25: 836-847https://doi.org/10.1038/s41556-023-01146-4 Crossref PubMed Scopus (4) Google Scholar uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities. A recent study by Yang et al. 1 Yang C. Zhao Y. Wang L. Guo Z. Ma L. Yang R. Wu Y. Li X. Niu J. Chu Q. et al. De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence. Nat. Cell Biol. 2023; 25: 836-847https://doi.org/10.1038/s41556-023-01146-4 Crossref PubMed Scopus (4) Google Scholar uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.