医学
恶化
哮喘
单克隆抗体
病理生理学
免疫学
耐火材料(行星科学)
免疫球蛋白E
免疫系统
抗体
内科学
生物
天体生物学
作者
Hana Serajeddini,Carmen Venegas Garrido,Anurag Bhalla,Melanie Kjarsgaard,Chynna Huang,Nicola LaVigne,Katherine Radford,Kayla Zhang,Terence Ho,Sarah Svenningsen,Manali Mukherjee,Parameswaran Nair
标识
DOI:10.1016/j.jaip.2022.09.036
摘要
Treatment with monoclonal antibodies (mAb) targeting IgE, IL-5, and IL-4/IL-13 pathways has become the standard strategy to manage severe asthmatics refractory to conventional therapies. Biologics are effective in improving symptom control, exacerbation rates, and oral corticosteroid (OCS) dependence.1 However, a subset of patients show suboptimal response, manifesting as persistent OCS use and functional decline.2 Given the complex relationship between cytokines, immune cells, and structural cells in driving the pathophysiology of asthma, it is conceivable that targeting a single pathway may be insufficient for optimal asthma control.
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