黄体期
医学
曲普瑞林
怀孕
胚胎移植
兴奋剂
胚泡移植
妊娠率
胚泡
促性腺激素释放激素激动剂
男科
体外受精
人绒毛膜促性腺激素
活产
卵母细胞
促性腺激素释放激素
内分泌学
内科学
激素
胚胎
促黄体激素
生物
受体
胚胎发生
细胞生物学
遗传学
作者
Ahmet Demir,Can Köse,Ebru Şahin Güleç,Pınar Türkmen,Emrah Töz,Nuri Peker
标识
DOI:10.5603/gp.a2022.0082
摘要
Luteal phase support with gonadotropin-releasing hormone agonist (GnRH-a) has been considered in terms of its potential beneficial effects on in vitro fertilisation (IVF) cycles. In our study, we assessed the effectiveness of single-dose GnRH-a administration in dual-triggered cycles on pregnancy outcomes.Eighty women who underwent intra cytoplasmic sperm injection (ICSI) cycle and had fresh blastocyst transfer were divided into two groups in terms of luteal phase support. The study group (Group A) consisted of patients (n = 40) who received a single-dose GnRH-a injection (0.1 mg of triptorelin acetate) subcutaneously 6 days after oocyte retrieval in addition to 600 mg daily of micronised progesterone, and the control group (Group B) comprised of patients (n = 40) taking 600 mg micronised progesterone daily from the first day after oocyte retrieval. GnRH-a and human chorionic gonadotropin (hCG; dual trigger) were administered to all patients. Comparison of the clinical pregnancy and live birth rates was our main goal.There was no significant difference between the two groups in terms of β-hCG positivity rates, clinical pregnancy rates and live birth rates (p value for beta-hCG = 0.25, clinical pregnancy = 0.80, live birth = 0.45).Our study demonstrated that in dual triggered cycles administration of a single dose of GnRH-a on the transfer day of a single blastocyst in addition to routine luteal phase support with progesterone does not statistically increase implantation, clinical pregnancy or live birth rates.
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