免疫系统
腺样囊性癌
免疫疗法
癌症研究
肿瘤浸润淋巴细胞
CD8型
免疫学
医学
生物
病理
癌
作者
Vishwajith Sridharan,Evisa Gjini,Xiaoyun Liao,Nicole G. Chau,Robert I. Haddad,Mariano Severgnini,Peter S. Hammerman,Adel K. El‐Naggar,Gordon J. Freeman,F. Stephen Hodi,Scott J. Rodig,Glenn Dranoff,Jonathan D. Schoenfeld
出处
期刊:Cancer immunology research
[American Association for Cancer Research]
日期:2016-07-31
卷期号:4 (8): 679-687
被引量:80
标识
DOI:10.1158/2326-6066.cir-16-0031
摘要
Adenoid cystic carcinoma (ACC) is among the most lethal salivary gland tumors, with no treatments for metastatic disease that prolong survival. We examined tissue from 28 primary and metastatic ACC deposits obtained from 21 patients for infiltrating immune cells and PD-L1/PD-L2 expression and determined mRNA profiles of over 1,400 oncogenic and immune-related genes. We also assessed the effect of chemoradiation on immune mediators in a patient who had serial biopsies available. Most tumors expressed PD-L2 but had few infiltrating immune cells. Lack of immune-cell infiltrate was associated with expression of genes in the β-catenin/Wnt and PI3K pathways. Additionally, certain transcripts linked to growth and invasion were differentially expressed among primary and metastatic deposits. Chemoradiation appeared to increase CD8(+) effector T cells, decrease regulatory T cells, and promote a systemic humoral response. These data suggest a potential role for PD-L2 inhibition and immune modulation as treatment for patients with ACC. Cancer Immunol Res; 4(8); 679-87. ©2016 AACR.
科研通智能强力驱动
Strongly Powered by AbleSci AI