堆积
折叠(DSP实现)
碱基对
基础(拓扑)
能量(信号处理)
核糖核酸
计算机科学
算法
核酸二级结构
数学
物理
化学
统计
工程类
DNA
数学分析
结构工程
基因
生物化学
核磁共振
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1989-04-07
卷期号:244 (4900): 48-52
被引量:1936
标识
DOI:10.1126/science.2468181
摘要
An algorithm and a computer program have been prepared for determining RNA secondary structures within any prescribed increment of the computed global minimum free energy. The mathematical problem of determining how well defined a minimum energy folding is can now be solved. All predicted base pairs that can participate in suboptimal structures may be displayed and analyzed graphically. Representative suboptimal foldings are generated by selecting these base pairs one at a time and computing the best foldings that contain them. A distance criterion that ensures that no two structures are "too close" is used to avoid multiple generation of similar structures. Thermodynamic parameters, including free-energy increments for single-base stacking at the ends of helices and for terminal mismatched pairs in interior and hairpin loops, are incorporated into the underlying folding model of the above algorithm.
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