Neuronal Regeneration after Stroke

Neurogenesis in the mammalian central nervous system was formerly considered to end shortly after birth. We now know that neural stem cells exist not only in the developing nervous system, but also in the nervous systems of all adult mammalian organisms, including humans.1 In the adult brain, new neurons are generated primarily in two regions: the subventricular zone and the subgranular zone1 of the hippocampal dentate gyrus. This neurogenesis occurs under normal conditions, and the generation of new neurons can increase under pathologic conditions, such as the brain ischemia that typifies a stroke.2 Whether newly formed neurons migrate to the . . .