小RNA
转录组
生物
RNA甲基化
核糖核酸
基因表达
生物发生
基因表达调控
甲基化
计算生物学
转录后调控
表观遗传学
基因
遗传学
甲基转移酶
作者
Ayşe Elif Erson-Bensan,Oguzhan Begik
出处
期刊:MicroRNA
日期:2017-08-16
卷期号:6 (2)
被引量:49
标识
DOI:10.2174/2211536606666170511102219
摘要
RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes.Here, we review recent literature on m6A modification and potential implications for microRNA (miRNA) mediated gene expression regulation. These implications involve miRNA biogenesis, mRNA-miRNA interactions and m6A target selection.Understanding the extent and functions of m6A is likely to improve our understanding of the complexities of the transcriptome regulation in normal and in disease states.
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