核糖核酸
基因
计算生物学
生物
基因组
鉴定(生物学)
酶
RNA编辑
遗传学
生物化学
植物
作者
Tsutomu Suzuki,Yoshiho Ikeuchi,Akiko Noma,Yuriko Sakaguchi
出处
期刊:Methods in Enzymology
日期:2007-01-01
卷期号:: 211-229
被引量:117
标识
DOI:10.1016/s0076-6879(07)25009-8
摘要
Posttranscriptional modifications are characteristic structural features of RNA molecules. To study the functional roles played by RNA modifications, it is necessary to identify the genes and enzymes that are responsible for their biosynthesis. Many uncharacterized genes for RNA modifications still remain buried in the genomes of model organisms. We describe here a systematic genomewide screening method that uses a reverse genetic approach combined with mass spectrometry, which we have named "ribonucleome analysis," to identify uncharacterized genes that are involved in generating RNA modifications.
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