甲磺酸
三乙胺
化学
产量(工程)
试剂
有机化学
冶金
材料科学
作者
Xavier Bertrand,Jean‐François Paquin
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-11-14
卷期号:21 (23): 9759-9762
被引量:13
标识
DOI:10.1021/acs.orglett.9b03950
摘要
The use of a methanesulfonic acid/triethylamine trihydrofluoride combination for the direct hydrofluorination of methallyl-containing substrates is reported. Under those metal-free conditions that use readily available, cheap, and easy to handle reagents, a range of methallyl alkenes could be converted to their corresponding tertiary fluoride in up to 78% yield. Finally, a promising result for the adaptation of this chemistry to continuous flow conditions is reported.
科研通智能强力驱动
Strongly Powered by AbleSci AI