传染性
病毒学
生物
克里米亚-刚果出血热
病毒
布尼亚病毒科
突变
滴答声
遗传学
基因
作者
Brian L Hua,Florine E. M. Scholte,Valerie Ohlendorf,Anne Kopp,Marco Marklewitz,Christian Drosten,Stuart T. Nichol,Christina F. Spiropoulou,Sandra Junglen,Éric Bergeron
出处
期刊:eLife
[eLife Sciences Publications Ltd]
日期:2020-10-21
卷期号:9
被引量:18
摘要
Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV, Nairoviridae) exhibits extensive genomic sequence diversity across strains (Deyde et al., 2006; Sherifi et al., 2014). It is currently unknown if genomic diversity is a factor contributing to variation in its pathogenicity. We obtained complete genome sequences of CCHFV directly from the tick reservoir. These new strains belong to a solitary lineage named Europe 2 that is circumstantially reputed to be less pathogenic than the epidemic strains from Europe 1 lineage. We identified a single tick-specific amino acid variant in the viral glycoprotein region that dramatically reduces its fusion activity in human cells, providing evidence that a glycoprotein precursor variant, present in ticks, has severely impaired function in human cells.
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