医学
癌细胞
鞘脂
胰腺癌
癌症
癌症研究
卵巢癌
黑色素瘤
细胞内
受体
白血病
神经母细胞瘤
细胞生物学
内科学
生物
细胞培养
遗传学
作者
Hong-Wei Yue,Qingchuan Jing,Pingping Li,Jing Liu,Wenjing Li,Jing Zhao
摘要
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an extracellular agent through G protein coupled receptors (GPCRs). Because of elevated levels of SPC in malicious ascites of patients with cancer, the role of SPC in tumor progression has prompted wide interest. The factor was reported to affect the proliferation and/or migration of many cancer cells, including pancreatic cancer cells, epithelial ovarian carcinoma cells, rat C6 glioma cells, neuroblastoma cells, melanoma cells, and human leukemia cells. This review covers current knowledge of the role of SPC in tumor.
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