长时程增强
突触可塑性
神经科学
变质塑性
海马体
记忆巩固
突触素
NMDA受体
镁
神经促进
神经传递
突触疲劳
促进
神经可塑性
突触标度
海马结构
非突触性可塑性
心理学
认知
化学
生物
受体
医学
内科学
生物化学
有机化学
免疫组织化学
作者
Inna Slutsky,Nashat Abumaria,Long Jun Wu,Chao Huang,Ling Zhang,Bo I. Li,Xiang Zhao,Arvind Govindarajan,Ming Gao Zhao,Min Zhuo,Susumu Tonegawa,Guosong Liu
出处
期刊:Neuron
[Elsevier]
日期:2010-01-28
卷期号:65 (2): 165-177
被引量:248
标识
DOI:10.1016/j.neuron.2009.12.026
摘要
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions.
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