Guillain‐Barré syndrome associated with CASPR2 antibodies: two paediatric cases

Abstract The pathogenesis of Guillain‐Barré syndrome ( GBS ) is considered to be, at least in part, mediated by autoantibodies directed against neuronal antigens. Antibodies to contactin‐associated protein‐like 2 ( CASPR2 ), part of the voltage‐gated potassium channel complex ( VGKC ‐complex), are associated with neurological disease predominantly affecting the peripheral nervous system but are not known to be associated with GBS . We report two cases of ganglioside antibody‐negative paediatric GBS associated with CASPR2 antibodies. Both patients made a complete clinical recovery. The tissue distribution and function of CASPR2 make it a biologically plausible autoimmune target in GBS and its clinical relevance in GBS should be determined in further studies.