化学
四糖
立体选择性
区域选择性
鼠李糖
立体化学
衍生工具(金融)
保护组
糖基
三糖
部分
糖基供体
多糖
作者
Vince Pozsgay,Cornelis P.J. Glaudemans,John B. Robbins,Rachel Schneerson
出处
期刊:Tetrahedron
[Elsevier]
日期:1992-11-20
卷期号:48 (47): 10249-10264
被引量:28
标识
DOI:10.1016/s0040-4020(01)88331-9
摘要
Abstract A glycosyl trichloroacetimidate derivative ( 1 ) of the tetrasaccharide α- d -Gal p -(1→3)-α- d -Glc p NAc-(1→3)-α-L-Rha p -(1→3)-α-L-Rha p was synthesized in a highly stereoselective, stepwise manner, using methyl 1-thioglycosides of L-rhamnose, 2-azido-2-deoxy-D-glucose and D-galactose, as major intermediates. The protecting group scenario in compound 1 permits regioselective deblocking at its “non-reducing end” unit. Therefore 1 is a suitable intermediate for the preparation of extended fragments of the title polysaccharide.
科研通智能强力驱动
Strongly Powered by AbleSci AI