抗生素
致病菌
库存
纳米技术
抗菌剂
抗生素耐药性
适应(眼睛)
业务
生化工程
风险分析(工程)
细菌
生物
微生物学
工程类
材料科学
政治学
神经科学
遗传学
法学
作者
Cheng Weng,Yong Leng Kelvin Tan,Woon‐Puay Koh,Wee Han Ang
标识
DOI:10.1002/anie.202310040
摘要
Antimicrobial resistance, caused by persistent adaptation and growing resistance of pathogenic bacteria to overprescribed antibiotics, poses one of the most serious and urgent threats to global public health. The limited pipeline of experimental antibiotics in development further exacerbates this looming crisis and new drugs with alternative modes of action are needed to tackle evolving pathogenic adaptation. Transition metal complexes can replenish this diminishing stockpile of drug candidates by providing compounds with unique properties that are not easily accessible using pure organic scaffolds. We spotlight four emerging strategies to harness these unique properties to develop new targeted antibacterial agents.
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