促炎细胞因子
下调和上调
失调
免疫系统
化学
炎症
炎症性肠病
分子生物学
生物
免疫学
医学
内科学
肠道菌群
生物化学
基因
疾病
作者
Yanru Ma,Xinyu Zhang,Baoqin Xuan,Danjie Li,Nan Yin,Lijun Ning,Yilu Zhou,Yuqing Yan,Tianying Tong,Xiaoqiang Zhu,Xiaowen Huang,Muni Hu,Zhenhua Wang,Zhe Cui,Hua‐Bin Li,Jiqiu Wang,Jing‐Yuan Fang,Ruixin Liu,Haoyan Chen,Jie Hong
出处
期刊:Gut
[BMJ]
日期:2023-09-21
卷期号:73 (2): 268-281
被引量:50
标识
DOI:10.1136/gutjnl-2023-330009
摘要
FTO downregulation promoted UC by decreasing CerS6 expression, leading to increased S1P accumulation in IECs and aggravating colitis via m6A-dependent mechanisms. Lower FTO expression in UC patients may enhance their response to vedolizumab treatment.
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