仿形(计算机编程)
转录组
克罗恩病
基因
作文(语言)
生物
基因表达
计算生物学
疾病
医学
内科学
遗传学
计算机科学
艺术
文学类
操作系统
作者
Kyuwon Kim,Sojung Park,Yoonho Lee,Jiwon Baek,Yong-Jae Kim,Sung Wook Hwang,Jong Lyul Lee,Sang Hyoung Park,Suk‐Kyun Yang,Buhm Han,Kyuyoung Song,Yong Sik Yoon,Ho‐Su Lee,Byong Duk Ye
出处
期刊:Journal of Crohn's and Colitis
[Oxford University Press]
日期:2023-08-18
卷期号:18 (2): 223-232
标识
DOI:10.1093/ecco-jcc/jjad141
摘要
Creeping fat [CF] is a poorly understood feature of Crohn's disease [CD], characterized by the wrapping of mesenteric adipose tissue [MAT] around the inflamed intestine. The aim of this study was to investigate the transcriptional profile and compositional features of CF.We collected 59 MAT samples: 23 paired samples from patients with CD (CF [CD-CF] and MAT around the uninflamed intestine [CD-MAT]) and 13 MAT samples from non-CD patients [Con-MAT]. Differentially expressed gene [DEG], functional pathway, cell deconvolution, and gene co-expression network analyses were performed.By comparing three different MAT samples, we identified a total of 529 DEGs [|log2FoldChange| > 1.5; false discovery rate < 0.05]. Of these, 323 genes showed an incremental pattern from Con-MAT to CD-MAT, and to CD-CF, while 105 genes displayed a decremental pattern. Genes with an incremental pattern were related to immune cell responses, including B- and T-cell activation, while genes with a decremental pattern were involved in cell trafficking and migration. Cell deconvolution analysis revealed significant changes in cellular composition between the CD-CF and Con-MAT groups, with increased proportions of B-cells/plasma cells [p = 1.16 × 10-4], T-cells [p = 3.66 × 10-3], and mononuclear phagocytes [p = 3.53 × 10-2] in the CD-CF group. In contrast, only the B-cell/plasma cell component showed a significant increase [p = 1.62 × 10-2] in the CD-MAT group compared to Con-MAT.The distinct transcriptional profiles and altered cellular components of each MAT found in our study provide insight into the mechanisms behind CF and highlight its possible role in the pathogenesis of CD.
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