丙二醛
氧化应激
过氧化氢酶
毒性
超氧化物歧化酶
化学
烟酰胺腺嘌呤二核苷酸磷酸
药理学
生物化学
医学
氧化酶试验
酶
有机化学
作者
Hongbin Yuan,Siyue Wen,Yu Zhao,Liehai Hu,Hengyi Xu
出处
期刊:Toxicology Research
[Oxford University Press]
日期:2023-04-27
卷期号:12 (3): 446-456
被引量:2
标识
DOI:10.1093/toxres/tfad031
摘要
Nanoplastics are widely distributed in the environment and can adsorb heavy metals, which poses a potential threat to human health through food chain. It is necessary to assess the combined toxicity of nanoplastics and heavy metals. The adverse effect of Pb and nanoplastics on liver, single or in combination, was evaluated in this study. The results showed that the Pb content in co-exposure group of nanoplastics and Pb (PN group) was higher than the group exposed to Pb alone (Pb group). And more severe inflammatory infiltration was observed in liver sections of PN group. The level of inflammatory cytokines and malondialdehyde were increased, while the superoxide dismutase activity was decreased in liver tissues of PN group. Moreover, the gene expression level of nuclear factor-erythroid 2-related factor 2, nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1 and catalase, which is related to antioxidation, was downregulated. And the expression level of cleaved-Caspase9 and cleaved-Caspase3 were increased. However, with the supplementation of oxidative stress inhibitor N-Acetyl-L-cysteine, liver damage shown in PN group was evidently alleviated. In summary, nanoplastics evidently exacerbated the deposition of Pb in liver and potentially aggravated the Pb-induced liver toxicity by activating oxidative stress.
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