急性放射综合征
电离辐射
造血
医疗辐射
食品药品监督管理局
辐射
医学
杀伤力
药品
动物模型
核医学
癌症研究
医学物理学
生物
辐照
药理学
内科学
毒理
物理
遗传学
干细胞
量子力学
核物理学
作者
P. Artur Plett,Louis M. Pelus,Christie M. Orschell
出处
期刊:Methods in molecular biology
日期:2022-10-19
卷期号:: 251-262
标识
DOI:10.1007/978-1-0716-2679-5_16
摘要
The hematopoietic system is one of the most sensitive tissues to ionizing radiation, and radiation doses from 2 to 10 gray can result in death from bleeding and infection if left untreated. Reviewing the range of radiation doses reported in the literature that result in similar lethality highlights the need for a more consistent model that would allow a better comparison of the hematopoietic acute radiation syndrome (H-ARS) studies carried out in different laboratories. Developing a murine model of H-ARS to provide a platform suited for efficacy testing of medical countermeasures (MCM) against radiation should include a review of the Food and Drug Administration requirements outlined in the Animal Rule. The various aspects of a murine H-ARS model found to affect consistent performance will be described in this chapter including strain, sex, radiation type and dose, mouse restraint, and husbandry.
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