Bone Remodeling Optimization in Orthodontics: Harnessing Periodontal Ligament Cell-derived Exosomes and Anti-inflammatory Compounds

AIM AND BACKGROUND: Exosomes transport biological information between cells and can influence periodontal tissue remodeling. Particularly, the periodontal ligament cells (PDLCs) receive mechanical stimuli and transmit them via exosomes to osteoblasts and assist in tissue remodeling during the orthodontic treatment. MATERIALS AND METHODS: This study uses computational methods to examine the effects of mechanical force-induced PDLC-transported exosomal micro RNA (miRNA) on osteoblast cells and to identify potential adjuvant therapies during orthodontic treatment. RESULTS: complex. CONCLUSION: Our study stipulates the molecular mechanisms that occurred in osteoblast cells upon mechanical stimuli in PDLC, which is critically useful to the development of adjuvant therapeutic molecules for the benefit of orthodontic treatment. CLINICAL SIGNIFICANCE: The crucial mechanism by which exosomes deliver miRNAs to the osteoblast cells capable of inhibiting the significant genes/mRNAs could benefit orthodontic treatment. How to cite this article: Alhazmi AS. Bone Remodeling Optimization in Orthodontics: Harnessing Periodontal Ligament Cell-derived Exosomes and Anti-inflammatory Compounds. J Contemp Dent Pract 2025;26(1):77-85.