Effectiveness of various exercise types in reducing fall risk among older adults with diabetic peripheral neuropathy: A systematic review and meta-analysis

Diabetic peripheral neuropathy (DPN) increases fall risk in diabetics. Due to varying variables used to assess fall risk, the impact of exercise on fall prevention remains inconsistent. This study reviews and compares the effects of different exercises on fall risk among older adults with DPN. A comprehensive literature search was conducted in PubMed, EBSCO, Web of Science, and Cochrane Library up to February 17th, 2025. Inclusion criteria were: older adults with DPN; exercise intervention only, an inactive or non-exercising control group, and randomized controlled trials with outcome variables: timed up and go (TUG) time, gait speed, Berg Balance Scale (BBS) score, one-legged standing (OLS) time with eye open (EO) and closed (EC). The mean difference (MD) and 95 % confidence interval (CI) were calculated. A total of 21 articles included five exercise types: balance exercise (BE), multi-component exercise (ME), strength exercise (SE), whole-body vibration (WBV) and foot-ankle functional training (FT). BE reduced TUG time (MD = -1.47, 95 % CI = -1.79 to -1.15) and increased gait speed (0.11, 0.04-0.18), BBS score (0.93, 0.49-1.37), and OLS time (EO: 2.72, 1.86-3.58; EC:1.58, 1.0-2.17). ME reduced TUG time (-1.71, -2.26 to -1.17) and increased BBS score (2.0, 1.28-2.72) and OLS time (EO: 7.07, 4.35-9.79; EC: 2.61, 1.28-3.94); SE reduced TUG time (-1.45, -2.75 to -0.15) and increased gait speed (0.09, 0.06-0.12); WBV increased OLS time (EO: 1.94, 1.32-2.56; EC: 1.86, 0.16-3.56) but did not affect TUG time or gait speed. FT did not affect TUG time or gait speed. Exercise reduced fall risks among older adults with DPN. BE and ME were effective in reducing fall risks, followed by SE. WBV improved static balance but failed in dynamic balance. FT showed limited effects on fall prevention and was not recommended.