Numerical analysis of oscillating microbubbles coated with a lipid monolayer near a flexible tissue

Over the past two decades, ultrasound has advanced as a non-invasive drug delivery method. However, cavitation may cause cytoskeletal damage and cell death. This study numerically analyzes a compressible lipid-coated bubble near flexible tissue using Lattice Boltzmann and finite element methods. At 200 and 400 KPa ultrasound pressures, results show increased shear stress, boundary deformation, and bubble dynamics. The elastic boundary raises the bubble's resonance frequency. Shear stress rises from 0.09 to 0.61 KPa and 0.11 to 1.1 KPa during compression and expansion. A multi-pseudo-potential LBM improves cavitation modeling, revealing how proximity to cells intensifies pressure effects.