化学
级联
光催化
可见光谱
光化学
组合化学
光催化
光电子学
有机化学
催化作用
色谱法
物理
作者
Shruti Rajput,Dimple Garg,Nidhi Jain
标识
DOI:10.1002/adsc.202400026
摘要
A photoinduced direct synthesis of 3‐amino‐1‐indenones via radical cascade cyclization strategy is demonstrated. The methodology involves a domino reaction between 2‐alkynylarylnitrile and N‐aminopyridinium salt and captures the reactivity of in‐situ generated nitrogen‐centered radical (NCR) in visible light. Multiple bond‐forming events including C‐N, C‐C, and C‐O take place sequentially on 2‐alkynylarylnitrile enabling construction of 3‐amino‐1‐indenone core at room temperature in 35‐76% yields. A preliminary biological screening of synthesized compounds is indicative of their potent anti‐cancer property.
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