化学
苯并咪唑
咪唑
组合化学
羧酸盐
试剂
可药性
立体化学
有机化学
生物化学
基因
作者
Gullahalli S. Jagadeesha,N. R. Thimmegowda,Kempegowda Mantelingu,Prasanna D. Shivaramu,Kanchugarakoppal S. Rangappa
出处
期刊:Asian Journal of Chemistry
[Asian Journal of Chemistry]
日期:2023-01-01
卷期号:35 (3): 598-604
标识
DOI:10.14233/ajchem.2023.27480
摘要
A novel microwave assisted protocol for the rapid synthesis of methyl 1-benzyl-2-(4-fluoro-3- nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate (TJ08) with potent antileukemic activity has been developed with excellent yields in 31 min of reaction time over 5 steps, whereas the conventional heating method required around 17 h. In this method, n-propanephosphonic acid anhydride (T3P) was used as a coupling reagent for amidation, during this reaction the in situ generated byproduct n-propylphosphonic acid subsequently catalyzes the cyclization reaction to form benzimidazole ring and hence this novel protocol affords to synthesize the novel benzimidazole derivatives expeditiously to develop new druggable compounds.
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