炎症
医学
冲程(发动机)
脑损伤
神经科学
血脑屏障
脑缺血
缺血
内科学
病理
小胶质细胞
免疫学
中枢神经系统
生物
机械工程
工程类
作者
Kaibin Shi,De-Cai Tian,Zhiguo Li,Andrew F. Ducruet,Michael T. Lawton,Fu‐Dong Shi
标识
DOI:10.1016/s1474-4422(19)30078-x
摘要
Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death. In addition to inflammation localised to the injured brain region, a growing body of evidence suggests that inflammatory responses after a stroke occur and persist throughout the entire brain. Global brain inflammation might continuously shape the evolving pathology after a stroke and affect the patients' long-term neurological outcome. Future efforts towards understanding the mechanisms governing the emergence of so-called global brain inflammation would facilitate modulation of this inflammation as a potential therapeutic strategy for stroke.
科研通智能强力驱动
Strongly Powered by AbleSci AI