橙皮素
橙皮苷
临床试验
医学
生物利用度
苷元
药理学
健康福利
传统医学
替代医学
化学
内科学
糖苷
病理
有机化学
作者
Bahare Salehi,Natália Cruz‐Martins,Monica Butnariu,Ioan Sărac,Iulia Cristina Bagiu,Shahira M. Ezzat,Jinfan Wang,Aaron Koay,Helen Sheridan,Charles Oluwaseun Adetunji,Prabhakar Semwal,Mauricio Schoebitz,Miquel Martorell,Javad Sharifi‐Rad
标识
DOI:10.1080/10408398.2021.1875979
摘要
Flavonoids are common in the plant kingdom and many of them have shown a wide spectrum of bioactive properties. Hesperetin (Hst), the aglycone form of hesperidin, is a great example, and is the most abundant flavonoid found in Citrus plants. This review aims to provide an overview on the in vitro, in vivo and clinical studies reporting the Hst pharmacological effects and to discuss the bioavailability-related issues. Preclinical studies have shown promising effects on cancer, cardiovascular diseases, carbohydrate dysregulation, bone health, and other pathologies. Clinical studies have supported the Hst promissory effects as cardioprotective and neuroprotective agent. However, further well-designed clinical trials are needed to address the other Hst effects observed in preclinical trials, as well as to a more in-depth understanding of its safety profile.
科研通智能强力驱动
Strongly Powered by AbleSci AI