生物催化
辅因子
微型反应器
化学
金属有机骨架
纳米技术
催化作用
材料科学
酶
有机化学
反应机理
吸附
作者
Jieying Liang,Song Gao,Jian Liu,Muhammad Yazid Bin Zulkifli,Jiangtao Xu,Jason Scott,Vicki Chen,Jiafu Shi,Aditya Rawal,Kang Liang
标识
DOI:10.1002/anie.202014002
摘要
Abstract Metal‐organic frameworks (MOFs) have recently emerged as excellent hosting matrices for enzyme immobilization, offering superior physical and chemical protection for biocatalytic reactions. However, for multienzyme and cofactor‐dependent biocatalysis, the subtle orchestration of enzymes and cofactors is largely disrupted upon immobilizing in the rigid crystalline MOF network, which leads to a much reduced biocatalytic efficiency. Herein, we constructed hierarchically porous MOFs by controlled structural etching to enhance multienzyme and cofactor‐dependent enzyme biocatalysis. The expanded size of the pores can provide sufficient space for accommodated enzymes to reorientate and spread within MOFs in their lower surface energy state as well as to decrease the inherent barriers to accelerate the diffusion rate of reactants and intermediates. Moreover, the developed hierarchically porous MOFs demonstrated outstanding tolerance to inhospitable surroundings and recyclability.
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