Continuous Microwave-Assisted Synthesis of Silver Nanoclusters Confined in Mesoporous SBA-15: Application in Alkyne Cyclizations

Optimization of heating time in batch synthesis (Figure S1); physical and geometrical parameters adopted for Comsol Multiphysics simulation (Table S1); N2 adsorption analysis (Table S2); reproducibility analysis (Figure S2); TEM and HRSTEM characterization of SBA-15, unsupported Ag NCs, and Ag NCs/SBA-15 with 0.16, 0.62, and 0.96 wt % (Figure S3); leaching test for propargylguanidine cyclization (Figure S4, Table S3, and Figure S5); catalytic reusability and stability study by reaction of 2-(phenylethynyl)phenol (Figure S6); continuous flow reaction and activation energy for 2-(phenylethynyl)phenol cyclization (figure S7); reaction mechanism for hydroamination of propargylguanidines (Scheme S1); general procedure for the synthesis of starting material with corresponding characterization data.