化学
选择性
药代动力学
化学合成
药理学
PI3K/AKT/mTOR通路
基因亚型
结构-活动关系
体外
生物化学
立体化学
信号转导
基因
医学
催化作用
作者
Minna Bui,Xiaolin Hao,Youngsook Shin,Mario Cardozo,Xiao He,Kirk R. Henne,Julia Suchomel,John D. McCarter,Lawrence R. McGee,Tisha San Miguel,Julio C. Medina,Deanna Mohn,Thuy Tran,Sharon Wannberg,Jamie Wong,Simon Wong,Leeanne Zalameda,Daniela Metz,Timothy D. Cushing
标识
DOI:10.1016/j.bmcl.2015.01.001
摘要
2,3,4-Substituted quinolines such as (10a) were found to be potent inhibitors of PI3Kδ in both biochemical and cellular assays with good selectivity over three other class I PI3K isoforms. Some of those analogs showed favorable pharmacokinetic properties.
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