Clathriol, a Novel Polyoxygenated 14β Steroid Isolated from the New Zealand Marine Sponge Clathria lissosclera

Clathriol (1), a highly oxygenated steroid with the unusual 14beta configuration, was isolated from the New Zealand marine sponge Clathria lissosclera. The structure was elucidated from a combination of NMR and mass spectroscopy. Clathriol showed in vitro antiinflammatory activity against human neutrophyl and rat mast cells.