Near-infrared light control of GelMA/PMMA/PDA hydrogel with mild photothermal therapy for skull regeneration

The development of bone tissue engineering indicates some new paths for bone defect repair. Mild photothermal therapy (PTT) is flourishing as an exciting potential method for bone regeneration. Polydopamine nanoparticles exhibit good absorption at infrared wavelengths and can be used as a viable option for the application of mild PTT to bone defects. Herein, a gelatin-methacryloyl/poly(methyl methacrylate)/polydopamine (GelMA/PMMA/PDA) hydrogel was formulated and assessed in terms of mechanical and biological features. We observed that the addition of methacryloyl groups into gelatin and the introduction of PMMA improved the mechanical properties of the hydrogel and ensure the biosecurity. The GelMA/PMMA/PDA hydrogel demonstrated favorable photothermal ability, biocompatibility, and osteogenic effect. In the rat skull defect model, the GelMA/PMMA/PDA hydrogel with mild PTT possesses better bone repair compared with hydrogel-only and control groups. Thus, this mild photothermal hydrogel platform has a beneficial osteogenic ability and provides a novel approach to treat bone defects.