创伤性脑损伤
医学
病态的
神经科学
病理生理学
生物信息学
生物
免疫学
病理
精神科
作者
Ziqi Zhao,Yuan Zhou,Ye Tian,Min Li,Jing‐fei Dong,Jianning Zhang
出处
期刊:Protein & Cell
[Springer Nature]
日期:2017-05-02
卷期号:8 (11): 801-810
被引量:36
标识
DOI:10.1007/s13238-017-0414-6
摘要
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The finding that cellular microparticles (MPs) generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.
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