泡桐
细胞凋亡
细胞培养
细胞毒性T细胞
A549电池
传统医学
癌细胞
立体化学
细胞
癌细胞系
化学
癌症
医学
生物化学
体外
植物
生物
内科学
遗传学
作者
Cheng-mei Xiao,Jun Li,Lingtao Kong,Limin Xia,Lijun Shi,Chaoyue Zhao,Wen-Zhao Tang,Xian-hui Jia
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-07-01
卷期号:168: 105542-105542
标识
DOI:10.1016/j.fitote.2023.105542
摘要
Seven new C-geranylated flavanones, fortunones F - L (1–7), were isolated from the fresh mature fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were determined by extensive spectroscopic data interpretation (UV, IR, HRMS, NMR, and CD). These new isolated compounds were all with a cyclic side chain modified from the geranyl group. Among them, compounds 1–3 all possessed a dicyclic geranyl modification, which was described firstly for Paulownia C-geranylated flavonoids. All the isolated compounds were subjected to the cytotoxic assay on human lung cancer cell A549, mouse prostate cancer cell RM1 and human bladder cancer cell T24, respectively. Results indicated A549 cell line was more sensitive to C-geranylated flavanones than the other two cancer cell lines and compounds 1, 7 and 8 exhibited potential anti-tumor effects (IC50 ˂ 10 μM). Further research revealed the effective C-geranylated flavanones could exert their anti-proliferative activity on A549 cells by inducing apoptosis and blocking cells in G1 phase.
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