Dual‐Gate Organic Electrochemical Transistors Based on Laser‐Scribed Graphene for Detecting Dopamine and Glutamate

Abstract Organic electrochemical transistors (OECTs) are gaining significant attention due to their high sensitivity, customizability, ease of integration, and low‐cost manufacturing. In this paper, we design and develop a flexible dual‐gate OECT based on laser‐scribed graphene (LSG) with modified OECT gates for the detection of dopamine and glutamate, two critical neurotransmitters (NTs). The developed OECTs are fully carbon‐based and environmentally friendly. By modifying the gates of OECTs with biopolymer chitosan and L‐Glutamate oxidase enzyme, highly selective and sensitive measurements are successfully achieved with detection limits of 5 n m for dopamine and 1 µ m for glutamate, respectively. The modified dual‐gate shows no interference between the detections of two neurotransmitters, making it a promising tool for customized multi‐neurotransmitter analysis. The results demonstrate the potential of LSG‐based OECTs in customizable biosensing applications, offering a flexible, cost‐effective platform for biomedical disorder diagnostics.