Recent Advances in Deoxygenative Thioether Synthesis Using Oxygenated Sulfur Surrogates

Abstract Thioethers (sulfides) play a crucial role in therapeutics, diagnostics, and functional materials. Traditionally, their synthesis involved the use of thiols or their derivatives, which are associated with unpleasant odors and potential health risks. Recently, significant research has focused on employing oxygenated sulfur compounds, such as sulfinates, sulfonyl derivatives, sulfur oxyacids, and sulfoxides, as thiol surrogates for thioether synthesis. This review highlights recent advancements in deoxygenative thioether synthesis, categorizing them by reaction types, including cross-coupling reactions, C–H functionalization, and hydro/halo/oxy-thiolation of unsaturated hydrocarbons. We also discuss representative mechanisms to provide a comprehensive understanding of these innovative approaches. 1 Introduction 2 Cross-Coupling Reactions 3 C–H Functionalization 4 Hydro/Halo/Oxy-thiolation of Unsaturated Hydrocarbons 5 Conclusion