The evolving paradigm and current perception of hypertrophic cardiomyopathy: Implications for management

医学 肥厚性心肌病 自然史 生活质量(医疗保健) 疾病 重症监护医学 临床试验 流行病学 病理 心脏病学 内科学 护理部
作者
Annamaria Del Franco,Silvia Menale,Chiara Chiti,Giulia Biagioni,Alessia Tomberli,Mattia Zampieri,Iacopo Olivotto
出处
期刊:Progress in Cardiovascular Diseases [Elsevier]
卷期号:80: 8-13 被引量:1
标识
DOI:10.1016/j.pcad.2023.08.002
摘要

Recent evidence from imaging and genetic screening studies has clearly shown that hypertrophic cardiomyopathy (HCM) is more common than initially perceived, emphasizing the need to reassess its associated clinical and social burden. While clinical and academic efforts have long been focused on stratification of arrhythmic risk and management of intraventricular obstruction, progression of cardiac dysfunction and heart failure-related complications have emerged as most relevant from the epidemiological standpoint, delineating a major unmet need. Furthermore, a broader perspective of our patients' needs has become central in the care of individuals with HCM, addressing issues that are not strictly clinical but equally important to their wellbeing, such as quality of life, athletic participation, lifestyle and reproductive choices and psychological adaptation to a chronic condition often detected at a young age. The appropriate evaluation and objective assessment of disease burden associated with HCM are increasingly relevant not only to management but also to trial design and evaluation of the efficacy of emerging, targeted treatments. In this review, we discuss the evolving perception of HCM prevalence and natural history, as well as recent acquisitions regarding its true, often under-appreciated socio-economic and clinical burden.
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