选择性
化学
基质(水族馆)
空位缺陷
检出限
催化作用
吸附
显色的
吸收(声学)
氧化还原
无机化学
物理化学
材料科学
结晶学
色谱法
有机化学
海洋学
复合材料
地质学
作者
Changzheng Sun,Zhiyong Xue,Hao Huang,Ya Liu,X. H. Mo,Yukuan Feng,Jiahong Wang,W. P. Zhou,Paul K. Chu,Xue‐Feng Yu,Wenxin Liu
标识
DOI:10.1016/j.bios.2023.115665
摘要
Nanozymes with enzyme-like characteristics have drawn wide interest but the catalytic activity and substrate selectivity of nanozymes still need improvement. Herein, Se-vacancy-rich TiSe2-x@Au nanocomposites are designed and demonstrated as nanozymes. The TiSe2-x@Au nanocomposites show excellent peroxidase-like activity and the chromogenic substrate p-phenylenediamine (PPD) can be selectively oxidized to compounds that exhibit an absorption peak at 413 nm that differs from that of self-oxidation or generally oxidized species, suggesting high catalytic activity and strong substrate selectivity. Theoretical calculations reveal that the PPD adsorption geometry at Se vacancies with an adsorption energy of -3.00 eV shows a unique spatial configuration and charge distribution, thereby inhibiting the free reaction and promoting both the activity and selectivity in PPD oxidation. The TiSe2-x@Au colorimetric system exhibits a wide linear range of 0.015 mM-0.6 mM and a low detection limit of 0.0037 mM in the detection of glucose. The blood glucose detection performance for human serum samples is comparable to that of a commercial glucose meter in the hospital (relative standard deviation < 6%). Our findings demonstrate a new strategy for rapid and accurate detection of blood glucose and our results provide insights into the future design of nanozymes.
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