海马体
海马结构
树突棘
神经科学
萧条(经济学)
突触后密度
长时程增强
慢性应激
认知
内科学
NMDA受体
心理学
医学
内分泌学
受体
宏观经济学
经济
作者
Xuanjun Liu,Chun Hung Lin,Shuangyan Wang,Xiaoqi Yu,Yanbin Jia,Jinglong Chen
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2022-11-25
卷期号:78 (4): 611-618
被引量:4
标识
DOI:10.1093/gerona/glac222
摘要
Depression is one of the most common psychiatric diseases worldwide. With the increase in the number of depressive episodes, cognitive dysfunction may be accelerated. Although significant findings related to the pathogenesis of depression have been reported, the precise molecular mechanisms of depression-related cognitive disorders have not yet been fully clarified. In this study, we collected serum copper levels and evaluated cognitive functions in patients with major depressive disorder (MDD) and healthy controls. Furthermore, we adopted a chronic restraint stress paradigm to induce depressive-like behaviors in mice, namely stress mice, and C57BL/6J mice were regarded as naive mice. We further measured the copper levels in hippocampus and dendritic spines of hippocampal neurons in stress mice and naive mice. Besides, we evaluated the changes of N-methyl-D-aspartic acid receptor subunit 2B (GluN2B) and postsynaptic density protein 95 (PSD95) levels in hippocampus, and dendritic spines of hippocampal neurons in stress mice with a copper inhibitor. The results revealed that high levels of copper and decreased memory scores exhibited a significant correlation in MDD patients. We further found that the copper inhibitor increased GluN2B and PSD95 levels in hippocampus, which could be involved in the regulation of dendritic spines of hippocampal neurons in stress mice. These results suggested that high levels of copper suppressed GluN2B and PSD95 levels in hippocampus, damaged synaptic function, and caused memory disorders in depression. Our findings provided a promising perspective for high levels of copper in patients with depression-related cognitive disorders, and copper may even be targeted for therapeutic manipulation.
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