化学
呋喃
分子内力
双键
催化作用
药物化学
串联
环加成
甲酸
去甲基化
三键
布朗斯特德-洛瑞酸碱理论
苯
分子内反应
立体化学
有机化学
生物化学
材料科学
基因表达
DNA甲基化
复合材料
基因
作者
Sen Zhang,Hongfei Zhu,Jingning Xi,S. F. Wang,Xin Chang,C. P. Shen,Yong Feng,Zhaoyang Zhang,Mengting Zhao,Likun Zhang,Mi Li,Xiaojie Jin,An‐Xi Zhou,Ni-Ni Zhou
标识
DOI:10.1021/acs.joc.3c02300
摘要
A metal-free and atom-economic route for the synthesis of naphtho[1,2-b]furan-3-ones has been realized via p-TsOH·H2O-catalyzed intramolecular tandem double cyclization of γ-hydroxy acetylenic ketones with alkynes in formic acid. The benzene-linked furanonyl-ynes are the key intermediates obtained by the scission/recombination of C–O double bonds. Further, the structural modifications of the representative product were implemented by reduction, demethylation, substitution, and [5 + 2]-cycloaddition.
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