医学
神经调节
神经生理学
神经科学
慢性疼痛
物理医学与康复
感觉系统
刺激
认知
物理疗法
精神科
心理学
内科学
作者
T J Florence,Ausaf Bari,Andrew C. Vivas
标识
DOI:10.1016/j.nec.2023.11.004
摘要
Back pain is one of the most common aversive sensations in human experience. Pain is not limited to the sensory transduction of tissue damage; rather, it encompasses a range of nervous system activities including lateral modulation, long-distance transmission, encoding, and decoding. Although spine surgery may address peripheral pain generators directly, aberrant signals along canonical aversive pathways and maladaptive influence of affective and cognitive states can result in persistent subjective pain refractory to classical surgical intervention. The clinical identification of who will benefit from surgery—and who will not—is increasingly grounded in neurophysiology.
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