医学
骨关节炎
间充质干细胞
止痛药
不利影响
再生医学
生物信息学
生活质量(医疗保健)
物理疗法
干细胞
重症监护医学
麻醉
药理学
病理
替代医学
护理部
生物
遗传学
作者
Fatimah Almahasneh,Ejlal Abu-El-Rub,Ramada R Khasawneh
出处
期刊:World Journal of Stem Cells
[Baishideng Publishing Group Co (World Journal of Stem Cells)]
日期:2023-04-26
卷期号:15 (4): 196-208
标识
DOI:10.4252/wjsc.v15.i4.196
摘要
Osteoarthritis (OA) is the most common musculoskeletal disease, and it is a major cause of pain, disability and health burden. Pain is the most common and bothersome presentation of OA, but its treatment is still suboptimal, due to the short-term action of employed analgesics and their poor adverse effect profile. Due to their regenerative and anti-inflammatory properties, mesenchymal stem cells (MSCs) have been extensively investigated as a potential therapy for OA, and numerous preclinical and clinical studies found a significant improvement in joint pathology and function, pain scores and/or quality of life after administration of MSCs. Only a limited number of studies, however, addressed pain control as the primary end-point or investigated the potential mechanisms of analgesia induced by MSCs. In this paper, we review the evidence reported in literature that support the analgesic action of MSCs in OA, and we summarize the potential mechanisms of these antinociceptive effects.
科研通智能强力驱动
Strongly Powered by AbleSci AI