乳腺癌
癌症
发病机制
生物
癌症研究
Wnt信号通路
转移
信号转导
连环素
癌变
免疫系统
免疫学
细胞生物学
遗传学
作者
Paige Kluz,Ryan Kolb,Qing Xie,Nicholas Borcherding,Qi Liu,Yuewan Luo,Myung-Chul Kim,Linna Wang,Yinan Zhang,Wei Li,Christopher S. Stipp,Katherine N. Gibson-Corley,Chen Zhao,Hank H. Qi,Andrew M. Bellizzi,Andy Tao,Sonia L. Sugg,Ronald J. Weigel,Daohong Zhou,Xian Shen,Weizhou Zhang
出处
期刊:Oncogene
[Springer Nature]
日期:2020-02-10
卷期号:39 (14): 2877-2889
被引量:8
标识
DOI:10.1038/s41388-020-1203-x
摘要
Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 (CD177), a known neutrophil antigen, to be positively correlated with relapse-free, metastasis-free, or overall survival in breast cancer. In addition, CD177 expression is correlated with good prognosis in several other solid cancers including prostate, cervical, and lung. Focusing on breast cancer, we found that CD177 is expressed in normal breast epithelial cells and is significantly reduced in invasive cancers. Loss of CD177 leads to hyperproliferative mammary epithelium and contributes to breast cancer pathogenesis. Mechanistically, we found that CD177-deficiency is associated with an increase in β-catenin signaling. Here we identified CD177 as a novel regulator of mammary epithelial proliferation and breast cancer pathogenesis likely via the modulation of Wnt/β-catenin signaling pathway, a key signaling pathway involved in multiple cancer types.
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