Relationship between inflammasome and autophagy

Inflammasome, as an important innate immune component, can be activated by exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-related molecular patterns (DAMPs). Activation of the inflammasome involves the formation and oligomerisation of protein complexes, triggering the activation of caspase-1, leading to the release of proinflammatory cytokines interleukin 1β (IL-1β) and IL-18.At present, autophagy is considered as the main regulator of the inflammasome.Autophagy is involved in cellular homeostasis, an important intracellular processes that removes damaged organelles (such as mitochondria) and intracellular pathogens.Further study in the mechanism of mutual regulation inflammasome and autophagy is very important for understanding the occurrence and development of inflammatory diseases. Key words: Inflammasome; Autophagy; Caspase-1