Advances in research of stem cell therapy for ischemic myocardial disease

Ischemic myocardial disease is one of the major diseases affecting human health. Stem cell transplantation for treatment of ischemic myocardial diseases has become a hot research topic in recent years. Transplantation of stem cells can promote angiogenesis and heart tissue regeneration, reduce scarred area, and improve heart systolic function. However, results from clinical studies on stem cell therapy for ischemic myocardial disease are inconsistent, which could result from the source of stem cells, infusion ways, injection dosage, and follow-up time. Additionally, stem cell transplantation is associated with immune rejection, tumor formation, and other potential safety issues. The main objective of this review is to discuss the influencing factors and safety problems in stem cell therapy for ischemic myocardial disease. Key words: Ischemic myocardial disease; Cardiac repair; Stem cell transplantation; Mesenchymal stem cell