卵胞浆内精子注射
胚泡
男科
聚乙烯吡咯烷酮
胚胎质量
胚胎
化学
劈理(地质)
精液
胚胎发生
生物
医学
体外受精
高分子化学
细胞生物学
古生物学
断裂(地质)
作者
Ding Ding,Qiushuang Wang,Xinyuan Li,Beili Chen,Weiwei Zou,Dongmei Ji,Yan Hao,Rufeng Xue,Huijuan Zou,Zhaolian Wei,Ping Zhou,Yunxia Cao,Zhiguo Zhang
出处
期刊:Zygote
[Cambridge University Press]
日期:2020-01-14
卷期号:28 (2): 148-153
被引量:14
标识
DOI:10.1017/s0967199419000820
摘要
Summary To explore whether different polyvinylpyrrolidone (PVP) concentrations affect the results of intracytoplasmic sperm injection (ICSI), a prospective study was conducted for 194 couples undergoing 210 ICSI therapy cycles. These cycles were divided into three groups (10, 7 and 5% groups) using the corresponding concentration of PVP for sperm immobilization. The main outcome measures were analyzed. Results indicated that, with a decrease in PVP concentrations, all of the main outcome measures increased. In particular, the high-quality cleavage embryo rate in the 7% group was significantly lower than in the 5% group ( P < 0.01), and the cleavage, high-quality cleavage embryo, and high-quality blastocyst rates in the 5% group were significantly higher than those in the 10% group (all P < 0.001). For high-/intermediate-quality semen, all of the main outcome measures were significantly increased with 5% PVP. For the poor-quality semen, only the high-quality cleavage embryo and high-quality blastocyst rates were significantly higher in the 5% group. Therefore, lowering PVP concentrations greatly promoted the development of embryos in ICSI cycles, with an optimal concentration of 5% for ICSI.
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