抗体-药物偶联物
药品
医学
免疫结合物
连接器
结合
免疫毒素
单克隆抗体
细胞毒性T细胞
化学
药理学
癌症研究
抗体
免疫学
生物化学
计算机科学
数学
体外
数学分析
操作系统
作者
Zhiwen Fu,Shijun Li,Sifei Han,Shi Chen,Yu Zhang
标识
DOI:10.1038/s41392-022-00947-7
摘要
Antibody-drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells, which has become one of the hotspots for the research and development of anticancer drugs. Since the first ADC, Mylotarg
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